Dr. Mario & Puzzle League (also parsed Dr. Mario / Puzzle League, known as Dr. Mario & Panel de Pon in Japan) is a “2 in 1” game for the Game Boy Advance. Dr. Mario is an enhanced remake of the original Dr. Mario, using many of the graphics from Dr. Mario 64.
Puzzle League’s name probably comes from Pokémon Puzzle League, a game based on Tetris Attack, which is in turn based on the Japan-only Panel de Pon. This version, however, is a very simple form of the game.
A browser game, Dr. Mario Vitamin Toss, was released as a promotional tie-in with Dr. Mario & Puzzle League.
Dr. Mario mostly resembles the Nintendo 64 version, Dr. Mario 64. Like Dr. Wario, the unlockable minigame from WarioWare, Inc.: Mega Microgame$!, its bottle is 13 cells tall instead of the standard 16.
Puzzle League is completely changed from the original only Japan game Panel de Pon. The graphics closely resemble those of the GBA multiboot version from Nintendo Puzzle Collection. Both games have a vertical mode that can be unlocked, where one tilts the Game Boy Advance(SP) 90° counterclockwise to play, allowing for a higher resolution playing field.
Both games have a multi-pack multiplayer mode, but can download a demo version to another Game Boy Advance using only one cart. The demo version of Dr. Mario features limited animation and an NES soundtrack. The demo version of Puzzle League features a small animal (Pupuri from Panel de Pon) on the side that calls out when blocks are cleared. The demo of Puzzle League is also the same demo from Nintendo Puzzle Collection.